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KMID : 0383820140770030136
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Tuberculosis and Respiratory Diseases
2014 Volume.77 No. 3 p.136 ~ p.140
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Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome
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Kim Jung-Hoon
Song Won-Jun
Jun Ji-Eun
Ryu Duck-Hyun
Lee Ji-Eun
Jeong Ho-Jung
Jeong Suk-Hyeon
Kang Hyung-Koo
Kim Jung-Soo
Lee Hyun-Woo
Chon Hae-Ri
Jeon Kyeong-Man
Kim Do-Hun
Kim Jhin-Gook
Koh Won-Jung
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Abstract
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Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient’s condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.
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KEYWORD
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Kartagener Syndrome, Primary Ciliary Dyskinesia, Bronchiectasis, Nontuberculous Mycobacteria, Mycobacterium Infections, Nontuberculous
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